Now we know who Lee was but what about Wesley? While no definite proof is available, it is entirely possible that the street was named for Wesley Methodist Episcopal Church, South, built on the street shortly after the Civil War. The building in the background was originally named the Medical Arts Building, but after the Henson-Kickernick Company moved their headquarters into the building, it became known as the Henson Building. It’s one of the most elegant structures in Greenville.